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Selenium: Safeguarding Against Twin Lamb Disease in Sheep



Twin Lambs

Pregnancy toxaemia, also known as twin lamb disease, pregnancy toxicity or ketosis, is a condition that can affect pregnant ewes and their developing lambs. It occurs primarily in late pregnancy when the nutritional demands of the growing lambs surpass the ewe's ability to provide sufficient energy through her diet. In managing this condition, selenium, an essential trace element, plays a crucial role in ensuring the health of both the ewe and her offspring. In this blog post, we'll explore the connection between selenium and pregnancy toxicity in sheep and how proper supplementation can make a significant impact.


Understanding Pregnancy Toxicity in Sheep

Pregnancy toxicity is a metabolic disorder that arises when ewes experience a negative energy balance during late pregnancy. This imbalance results in the breakdown of fat reserves, leading to the production of ketones, which can be toxic. Common factors contributing to pregnancy toxicity include inadequate nutrition, stress, obesity, and multiple pregnancies.


The Role of Selenium

Selenium is a trace element essential for the proper functioning of various metabolic processes, including those involved in the liver's detoxification and antioxidant systems. Selenium acts as a cofactor for enzymes like glutathione peroxidase, which help protect cells from oxidative damage and maintain healthy metabolic functions. In sheep, selenium plays a critical role in preventing and managing pregnancy toxicity in the following ways:

  1. Antioxidant Defence: Selenium helps counteract oxidative stress by neutralizing harmful free radicals that can lead to lipid peroxidation and cell damage.

  2. Liver Function: A well-functioning liver is crucial for managing the breakdown of stored fats. Selenium supports the liver's ability to efficiently metabolize fat and produce energy without excessive ketone production.

  3. Immune System Support: Adequate selenium levels are essential for a robust immune response in ewes and their lambs, ensuring overall health.

Preventing and Managing Pregnancy Toxicity

To effectively prevent and manage pregnancy toxicity in sheep, it is essential to focus on proper nutrition and selenium supplementation:

  1. Balanced Diet: Ensuring that pregnant ewes receive a balanced diet with adequate energy and nutrients is fundamental. This includes providing enough high-quality forage, grains, and minerals.

  2. Selenium Supplementation: Depending on the selenium content in the local environment and feed sources, selenium supplementation may be necessary. Consult with a veterinarian to determine the appropriate selenium supplementation for your flock.

  3. Monitoring: Regularly monitor ewes for signs of ketosis, including loss of appetite, lethargy, and abnormal behaviour. Early detection allows for prompt intervention.


Selenium plays a vital role in preventing and managing pregnancy toxicity in sheep. By maintaining proper nutrition, supplementing selenium as needed, and closely monitoring pregnant ewes, you can help ensure the health and well-being of both the ewes and their precious lambs. A healthy and thriving flock of sheep starts with providing the right support during pregnancy, ultimately leading to the birth of strong and healthy lambs.




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